Morpheus

Author: Lutz Brusch

Aim:

• Define relation between experiment and theory, bottom-up versus top-down models
• See model as tool, get to know a success story

Description:

• Discuss previous experiences by students with models
• Ask expectations, explain schedule of week, day, when hands-on parts
• Present slides
• including

1. top-down success story [Herrgen et al. 2010]
2. Comparison of concepts
3. Model: model organism (model of human physiology) versus conceptual model (end of paper, static representation, flowchart) versus mathematical models (typically: dynamical system theory)
4. for mathematical models: analytical solution (extra insight) versus simulation, choose adequate model formalism, discrete versus continuous, deterministic versus stochastic, single-cell versus multicellular, bottom-up versus top-down
5. Historical overview of pattern formation

Paper:

• Herrgen, L., Ares, S., Morelli, L.G., Schröter, C., Jülicher, F., and Oates, A.C. (2010) Intercellular Coupling Regulates the Period of the Segmentation Clock. Curr. Biol. 20(14):1244-1253. PMID 20637620. link