Osvaldo Chara
Osvaldo Chara is principal investigator and group leader of SysBio, the Systems Biology group at the Institute of Physics of Liquids and Biological Systems (IFLySIB), National Scientific and Technical Research Council (CONICET) and University of La Plata, in La Plata, Argentina.
Osvaldo investigates tissue morphogenesis in development and regeneration by using mathematical modelling with a systems biology approach, always in collaboration with experimental colleagues.
Osvaldo holds a permanent position of Independent Researcher (“Investigador Independiente” in Spanish) of CONICET. He is also Full Professor at the Argentinian University of Business (UADE), where he carries on his teaching activities. Finally, he is also a guest researcher at the Zentrum für Informationsdienste und Hochleistungsrechnen (ZIH), Technische Universität Dresden (TUD), Dresden, where he worked as a senior postdoc a few years back.
Publications
2022
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Tig1 regulates proximo-distal identity during salamander limb regeneration
Nature Communications
2021
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Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration, eLife
2020
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A dynamic cell recruitment process drives growth of the Drosophila wing by overscaling the Vestigial expression pattern, Developmental Biology
2018
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Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells, Stem Cell Reports -
Sequence-dependent catalytic regulation of the SpoIIIE motor activity ensures directionality of DNA translocation
Sci Rep, 8, 1, 5254, 2018 [DOI]
2017
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Familial chilblain lupus due to a gain-of-function mutation in STING
Ann Rheum Dis, 76, 468-472 2017 [DOI]
2016
Live imaging of axolotl digit regeneration reveals spatiotemporal choreography of diverse connective tissue progenitor pools
Dev Cell,
39,
4
411-423,
2016
[DOI]
Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls
eLife,
5,
e20357,
2016
[DOI]
Leal Denis MF, Alvarez HA, Lauri N, Alvarez CL, Chara O, Schwarzbaum PJ. 2016. Dynamic Regulation of Cell Volume and Extracellular ATP of Human Erythrocytes. PLoS ONE, 11(6), e0158305. [DOI]
Vitali V, Sutka M, Amodeo G, Chara O, Ozu M. 2016. The Water to Solute Permeability Ratio Governs the Osmotic Volume Dynamics in Beetroot Vacuoles. Front Plant Sci. 7: 1388. [DOI]
2015
Cattoni DI, Chara O, Kaufman SB, Gonzalez-Flecha FL. 2015. Cooperativity in binding processes: New insights from phenomenological modeling. PLoS ONE, 10(12), e0146043. [DOI]
Chara O, Brusch L. 2015. Mathematical modelling of fluid transport and its regulation at multiple scales. BioSystems 130: 1-10. [DOI]
Günther C, Kind B, Reijns MA, Berndt N, Martinez-Bueno M, Wolf C, Tüngler V, Chara O, Lee YA, Hübner N, Bicknell L, Blum S, Krug C, Schmidt F, Kretschmer S, Koss S, Astell KR, Ramantani G, Bauerfeind A, Morris DL, Cunninghame Graham DS, Bubeck D, Leitch A, Ralston SH, Blackburn EA, Gahr M, Witte T, Vyse TJ, Melchers I, Mangold E, Nöthen MM, Aringer M, Kuhn A, Lüthke K, Unger L, Bley A, Lorenzi A, Isaacs JD, Alexopoulou D, Conrad K, Dahl A, Roers A, Alarcon-Riquelme ME, Jackson AP, Lee-Kirsch MA. 2015. Defective removal of ribonucleotides from DNA promotes systemic autoimmunity. J Clin Invest, 125(1), 413-24. [DOI]
Rodrigo Albors A, Tazaki A, Rost F, Nowoshilow S, Chara O, Tanaka E. 2015. Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration. eLife. [DOI]
2014
Blanco MV, Cattoni DI, Carriquiriborde P, Grigera JR, Chara O. 2014. Kinetics of bioaccumulation of heavy metals in Odontesthes bonariensis is explained by a single and common mechanism. Ecol. Mod. 274: 50-56.[DOI]
Chara O, Tanaka EM, Brusch L. 2014. Mathematical Modeling of Regenerative Processes. Curr Top Dev Biol. 108: 283-317.[DOI]
2013
Brusca MI, Irastorza RM, Cattoni DI, Ozu M, Chara O. 2013. Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study. Acta Odontol Scand. 71(3-4):416-423. [DOI]
Cattoni DI, Chara O, Godefroy C, Margeat E, Trigueros S, Milhiet PE, Nöllmann M. 2013. SpoIIIE mechanism of directional translocation involves target search coupled to sequence-dependent motor stimulation. EMBO Rep. 14(5): 473-479. [DOI]
Luksch H, Romanowski MJ, Chara O, Tungler V, Caffarena ER, Heymann MC, Lohse P, Aksentijevich I, Remmers EF, Flecks S, Quoos N, Gramatte J, Petzold C, Hofmann SR, Winkler S, Pessler F, Kallinich T, Ganser G, Nimtz-Talaska A, Baumann U, Runde V, Grimbacher B, Birmelin J, Gahr M, Roesler J, Rosen-Wolff A. 2013. Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1β. Hum Mutat. 34(1): 122-131. [DOI]
Roensch K, Tazaki A, Chara O, Tanaka EM. 2013. Progressive specification rather than intercalation of segments during limb regeneration. Science. 342(6164): 1375-9. [DOI]
Ozu M, Alvarez HA, McCarthy AN, Grigera JR, Chara O. 2013. Molecular dynamics of water in the neighborhood of aquaporins. Eur Biophys J. 42(4): 223-239. [DOI]
Tüngler V, Staroske W, Kind B, Dobrick M, Kretschmer S, Schmidt F, Krug C, Lorenz M, Chara O, Schwille P, Lee-Kirsch MA. 2013. Single-stranded nucleic acids promote SAMHD1 complex formation. J Mol Med (Berl). 91(6): 759-770. [DOI]
2012
Ferrara CG, Chara O, Grigera JR. 2012. Aggregation of non-polar solutes in water at different pressures and temperatures: The role of hydrophobic interaction. J Chem Phys. 137(13):135104. [DOI]
Alleva K, Chara O, Amodeo G. 2012. Aquaporins: Another piece in the osmotic puzzle. FEBS Lett. 586(19):2991-9. [DOI]
2011
Cattoni DI, Ravazzola C, Tüngler V, Wainstein DE & Chara O. 2011. Effect of intestinal pressure on fistula closure during vacuum assisted treatment: a computational approach. Int J Surg. 9(8):662-668. [DOI]
Chara O, Espelt MV , Krumschnabel G, Schwarzbaum PJ. 2011. Regulatory volume decrease and P receptor signaling in fish cells: mechanisms, physiology, and modeling approaches. J Exp Zool A Ecol Genet Physiol. 315A:175-202. [DOI]
Chara O, McCarthy AN, Grigera JR. 2011. Crossover between tetrahedral and hexagonal structures in liquid water. Phys Lett A. 375:572-576. [DOI]
Wainstein DE, Tüngler V, Ravazzola C, Chara O. 2011. Management of external small bowel fistulae: Challenges and controversies confronting the general surgeon. Int J Surg. 9(3):198-203. [DOI]
2010
Chara O, Pafundo DE, Schwarzbaum PJ. 2010. Negative feedback of extracellular ADP on ATP release in goldfish hepatocytes: a theoretical study. J Theor Biol. 264(4):1147-58. [DOI]
2009
Chara O, McCarthy AN, Ferrara CG, Caffarena ER, Grigera JR. 2009. Water behavior in the neighborhood of hydrophilic and hydrophobic membranes: Lessons from molecular dynamics simulations. Physica A. 388(21):4551-4559 [DOI]
Chara O, Pafundo DE, Schwarzbaum PJ. 2009. Kinetics of extracellular ATP from goldfish hepatocytes: a lesson from mathematical modeling. Bull Math Biol. 71(5):1025-47. [DOI]
Alleva K, Chara O, Sutka MR, Amodeo G. 2009. Analysis of the source of heterogeneity in the osmotic response of plant membrane vesicles. Eur Biophys J. 38(2):175-84. [DOI]
2008
Pafundo DE, Chara O, Faillace MP, Krumschnabel G, Schwarzbaum PJ. 2008. Kinetics of ATP release and cell volume regulation of hyposmotically challenged goldfish hepatocytes. Am J Physiol Regul Integr Comp Physiol. 294(1):R220-33. [DOI]
Wainstein DE, Fernandez E, Gonzalez D, Chara O, Berkowski D. 2008. Treatment of high-output enterocutaneous fistulas with a vacuum-compaction device. A ten-year experience. World J Surg. 32(3):430-5. [DOI]
Cattoni DI, Chara O. 2008. Vacuum effects over the closing of enterocutaneous fistulae: a mathematical modeling approach. Bull Math Biol. 70(1):281-96. [DOI]
2007
Chara O, Grigera JR, McCarthy AN. 2007. Studying the unfolding kinetics of proteins under pressure using long molecular dynamic simulation runs. J Biol Phys. 33(5-6):515-22. [DOI]
Brusca MI, Chara O, Sterin-Borda L, Rosa AC. 2007. Influence of different orthodontic brackets on adherence of microorganisms in vitro. Angle Orthod. 77(2):331-6. [DOI]
2005
Chara O, Ford P, Rivarola V, Parisi M, Capurro C. 2005. Asymmetry in the osmotic response of a rat cortical collecting duct cell line: role of aquaporin-2. J Membr Biol. 207(3):143-50. [DOI]
Rivarola V, Ford P, Chara O, Parisi M, Capurro C. 2005. Functional and molecular adaptation of Cl/HCO3- exchanger to chronic alkaline media in renal cells. Cell Physiol Biochem. 16(4-6):271-80. [DOI]
Ford P, Rivarola V, Chara O, Blot-Chabaud M, Cluzeaud F, Farman N, Parisi M, Capurro C. 2005. Volume regulation in cortical collecting duct cells: role of AQP2. Biol Cell. 97(9):687-97. [DOI]
2002
Ford P, Rivarola V, Kierbel A, Chara O, Blot-Chabaud M, Farman N, Parisi M, Capurro C. 2002. Differential role of Na+/H+ exchange isoforms NHE-1 and NHE-2 in a rat cortical collecting duct cell line. J Membr Biol. 190(2):117-25. [DOI]
