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TU Dresden
Dept. for Innovative
Methods of Computing

Osvaldo Chara

Osvaldo Chara received his Ph.D. from University of Buenos Aires for examining the physiology and biophysics of water transport in biological tissues with a focus on the role of aquaporins (membrane proteins that work as water channels). As a postdoc and later researcher at the Institute of Physics of Liquids and Biological Systems (IFLYSIB), La Plata, Argentina, he studied the physics of water near protein surfaces and membranes using molecular dynamics simulations.
His interests lie in the application of mathematical modeling and computer simulation to approach problems of different scientific fields including medicine (i.e. enterocutaneous fistulae). Based on experimental data he developed models to study the homeostasis of cell volume and kinetics of nucleotide release in different cell systems (i.e. goldfish, trout and rat hepatocytes, HepG2 cell line and human erythrocytes). In our group he is investigating the development and regeneration of tissues.


  • L. Manuel Muñoz-Nava, H. Ariel Alvarez, M. Flores-Flores, O. Chara, M. Nahmad
    A dynamic cell recruitment process drives growth of the Drosophila wing by overscaling the Vestigial expression pattern, Developmental Biology , 2020 [DOI]

  • J. Medelnik, K. Roensch, S. Okawa, A. del Sol, O. Chara, L. Mchedlishvili E. M. Tanaka
    Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells, Stem Cell Reports 10, 1751 - 1765, 2018 [DOI]

  • O. Chara, A. Borges, P.E. Milhiet, M. Nöllmann, D.I. Cattoni
    Sequence-dependent catalytic regulation of the SpoIIIE motor activity ensures directionality of DNA translocation
    Sci Rep, 8, 1, 5254, 2018 [DOI]

  • N. König, C. Fiehn, C. Wolf, M. Schuster, E. Cura Costa, V. Tüngler, HA. Alvarez, O. Chara, K. Engel, R. Goldbach-Mansky, C. Günther, MA. Lee-Kirsch
    Familial chilblain lupus due to a gain-of-function mutation in STING
    Ann Rheum Dis, 76, 468-472 2017 [DOI]


J.D. Currie, A. Kawaguchi, R.M. Traspas, M. Schuez, O. Chara, E.M. Tanaka
Live imaging of axolotl digit regeneration reveals spatiotemporal choreography of diverse connective tissue progenitor pools
Dev Cell, 39, 4 411-423, 2016 [DOI]

F. Rost, A. R. Albors, V. Mazurov, L. Brusch, A. Deutsch, E. M. Tanaka, O. Chara
Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls
eLife, 5, e20357, 2016 [DOI]

Leal Denis MF, Alvarez HA, Lauri N, Alvarez CL, Chara O, Schwarzbaum PJ. 2016. Dynamic Regulation of Cell Volume and Extracellular ATP of Human Erythrocytes. PLoS ONE, 11(6), e0158305. [DOI]

Vitali V, Sutka M, Amodeo G, Chara O, Ozu M. 2016. The Water to Solute Permeability Ratio Governs the Osmotic Volume Dynamics in Beetroot Vacuoles. Front Plant Sci. 7: 1388. [DOI]


Cattoni DI, Chara O, Kaufman SB, Gonzalez-Flecha FL. 2015. Cooperativity in binding processes: New insights from phenomenological modeling. PLoS ONE, 10(12), e0146043. [DOI]

Chara O, Brusch L. 2015. Mathematical modelling of fluid transport and its regulation at multiple scales. BioSystems 130: 1-10. [DOI]

Günther C, Kind B, Reijns MA, Berndt N, Martinez-Bueno M, Wolf C, Tüngler V, Chara O, Lee YA, Hübner N, Bicknell L, Blum S, Krug C, Schmidt F, Kretschmer S, Koss S, Astell KR, Ramantani G, Bauerfeind A, Morris DL, Cunninghame Graham DS, Bubeck D, Leitch A, Ralston SH, Blackburn EA, Gahr M, Witte T, Vyse TJ, Melchers I, Mangold E, Nöthen MM, Aringer M, Kuhn A, Lüthke K, Unger L, Bley A, Lorenzi A, Isaacs JD, Alexopoulou D, Conrad K, Dahl A, Roers A, Alarcon-Riquelme ME, Jackson AP, Lee-Kirsch MA. 2015. Defective removal of ribonucleotides from DNA promotes systemic autoimmunity. J Clin Invest, 125(1), 413-24. [DOI]

Rodrigo Albors A, Tazaki A, Rost F, Nowoshilow S, Chara O, Tanaka E. 2015. Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration. eLife. [DOI]


Blanco MV, Cattoni DI, Carriquiriborde P, Grigera JR, Chara O. 2014. Kinetics of bioaccumulation of heavy metals in Odontesthes bonariensis is explained by a single and common mechanism. Ecol. Mod. 274: 50-56.[DOI]

Chara O, Tanaka EM, Brusch L. 2014. Mathematical Modeling of Regenerative Processes. Curr Top Dev Biol. 108: 283-317.[DOI]


Brusca MI, Irastorza RM, Cattoni DI, Ozu M, Chara O. 2013. Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study. Acta Odontol Scand. 71(3-4):416-423. [DOI]

Cattoni DI, Chara O, Godefroy C, Margeat E, Trigueros S, Milhiet PE, Nöllmann M. 2013. SpoIIIE mechanism of directional translocation involves target search coupled to sequence-dependent motor stimulation. EMBO Rep. 14(5): 473-479. [DOI]

Luksch H, Romanowski MJ, Chara O, Tungler V, Caffarena ER, Heymann MC, Lohse P, Aksentijevich I, Remmers EF, Flecks S, Quoos N, Gramatte J, Petzold C, Hofmann SR, Winkler S, Pessler F, Kallinich T, Ganser G, Nimtz-Talaska A, Baumann U, Runde V, Grimbacher B, Birmelin J, Gahr M, Roesler J, Rosen-Wolff A. 2013. Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1β. Hum Mutat. 34(1): 122-131. [DOI]

Roensch K, Tazaki A, Chara O, Tanaka EM. 2013. Progressive specification rather than intercalation of segments during limb regeneration. Science. 342(6164): 1375-9. [DOI]

Ozu M, Alvarez HA, McCarthy AN, Grigera JR, Chara O. 2013. Molecular dynamics of water in the neighborhood of aquaporins. Eur Biophys J. 42(4): 223-239. [DOI]

Tüngler V, Staroske W, Kind B, Dobrick M, Kretschmer S, Schmidt F, Krug C, Lorenz M, Chara O, Schwille P, Lee-Kirsch MA. 2013. Single-stranded nucleic acids promote SAMHD1 complex formation. J Mol Med (Berl). 91(6): 759-770. [DOI]


Ferrara CG, Chara O, Grigera JR. 2012. Aggregation of non-polar solutes in water at different pressures and temperatures: The role of hydrophobic interaction. J Chem Phys. 137(13):135104. [DOI]

Alleva K, Chara O, Amodeo G. 2012. Aquaporins: Another piece in the osmotic puzzle. FEBS Lett. 586(19):2991-9. [DOI]


Cattoni DI, Ravazzola C, Tüngler V, Wainstein DE & Chara O. 2011. Effect of intestinal pressure on fistula closure during vacuum assisted treatment: a computational approach. Int J Surg. 9(8):662-668. [DOI]

Chara O, Espelt MV , Krumschnabel G, Schwarzbaum PJ. 2011. Regulatory volume decrease and P receptor signaling in fish cells: mechanisms, physiology, and modeling approaches. J Exp Zool A Ecol Genet Physiol. 315A:175-202. [DOI]

Chara O, McCarthy AN, Grigera JR. 2011. Crossover between tetrahedral and hexagonal structures in liquid water. Phys Lett A. 375:572-576. [DOI]

Wainstein DE, Tüngler V, Ravazzola C, Chara O. 2011. Management of external small bowel fistulae: Challenges and controversies confronting the general surgeon. Int J Surg. 9(3):198-203. [DOI]


Chara O, Pafundo DE, Schwarzbaum PJ. 2010. Negative feedback of extracellular ADP on ATP release in goldfish hepatocytes: a theoretical study. J Theor Biol. 264(4):1147-58. [DOI]


Chara O, McCarthy AN, Ferrara CG, Caffarena ER, Grigera JR. 2009. Water behavior in the neighborhood of hydrophilic and hydrophobic membranes: Lessons from molecular dynamics simulations. Physica A. 388(21):4551-4559 [DOI]

Chara O, Pafundo DE, Schwarzbaum PJ. 2009. Kinetics of extracellular ATP from goldfish hepatocytes: a lesson from mathematical modeling. Bull Math Biol. 71(5):1025-47. [DOI]

Alleva K, Chara O, Sutka MR, Amodeo G. 2009. Analysis of the source of heterogeneity in the osmotic response of plant membrane vesicles. Eur Biophys J. 38(2):175-84. [DOI]


Pafundo DE, Chara O, Faillace MP, Krumschnabel G, Schwarzbaum PJ. 2008. Kinetics of ATP release and cell volume regulation of hyposmotically challenged goldfish hepatocytes. Am J Physiol Regul Integr Comp Physiol. 294(1):R220-33. [DOI]

Wainstein DE, Fernandez E, Gonzalez D, Chara O, Berkowski D. 2008. Treatment of high-output enterocutaneous fistulas with a vacuum-compaction device. A ten-year experience. World J Surg. 32(3):430-5. [DOI]

Cattoni DI, Chara O. 2008. Vacuum effects over the closing of enterocutaneous fistulae: a mathematical modeling approach. Bull Math Biol. 70(1):281-96. [DOI]


Chara O, Grigera JR, McCarthy AN. 2007. Studying the unfolding kinetics of proteins under pressure using long molecular dynamic simulation runs. J Biol Phys. 33(5-6):515-22. [DOI]

Brusca MI, Chara O, Sterin-Borda L, Rosa AC. 2007. Influence of different orthodontic brackets on adherence of microorganisms in vitro. Angle Orthod. 77(2):331-6. [DOI]


Chara O, Ford P, Rivarola V, Parisi M, Capurro C. 2005. Asymmetry in the osmotic response of a rat cortical collecting duct cell line: role of aquaporin-2. J Membr Biol. 207(3):143-50. [DOI]

Rivarola V, Ford P, Chara O, Parisi M, Capurro C. 2005. Functional and molecular adaptation of Cl/HCO3- exchanger to chronic alkaline media in renal cells. Cell Physiol Biochem. 16(4-6):271-80. [DOI]

Ford P, Rivarola V, Chara O, Blot-Chabaud M, Cluzeaud F, Farman N, Parisi M, Capurro C. 2005. Volume regulation in cortical collecting duct cells: role of AQP2. Biol Cell. 97(9):687-97. [DOI]


Ford P, Rivarola V, Kierbel A, Chara O, Blot-Chabaud M, Farman N, Parisi M, Capurro C. 2002. Differential role of Na+/H+ exchange isoforms NHE-1 and NHE-2 in a rat cortical collecting duct cell line. J Membr Biol. 190(2):117-25. [DOI]