documentation:course:module1
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documentation:course:module1 [14:52 13.11.2017] – [Delta-Notch] Fabian Rost | documentation:course:module1 [16:20 13.11.2017] (current) – [Delta-Notch] Fabian Rost | ||
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* calculate steady state (do not calculate the stability, to complicated for biologists) | * calculate steady state (do not calculate the stability, to complicated for biologists) | ||
* simulate in morpheus | * simulate in morpheus | ||
+ | * typical models for biochemistry/ | ||
+ | |||
+ | < | ||
+ | digraph { | ||
+ | size=" | ||
+ | |||
+ | node [shape = circle]; | ||
+ | a[label="", | ||
+ | ab[label="", | ||
+ | c[label="", | ||
+ | |||
+ | a -> ab[arrowhead=None]; | ||
+ | ab -> A; | ||
+ | A -> c | ||
+ | B -> ab[arrowhead=tee]; | ||
+ | |||
+ | {rank=same; a; ab; A; c}; | ||
+ | } | ||
+ | |||
+ | </ | ||
+ | |||
+ | \begin{align} | ||
+ | \dot A &= \frac{\theta^n}{\theta^n + B^n} - k A | ||
+ | \end{align} | ||
==== Delta-Notch ==== | ==== Delta-Notch ==== | ||
Line 91: | Line 115: | ||
* this system is bistable for certain parameter ranges, if the students are advanced they might find this out themselves | * this system is bistable for certain parameter ranges, if the students are advanced they might find this out themselves | ||
- | * bistable e.g. for $\theta=0.1$, $n=4$, | + | * bistable e.g. for $\theta=0.5$, $n=4$, |
* if they have this system running in morpheus go spatial and let them simulate the system on a square and hexagonal grid | * if they have this system running in morpheus go spatial and let them simulate the system on a square and hexagonal grid | ||
* then you could also move to shaped cpm cells or even moving cells | * then you could also move to shaped cpm cells or even moving cells | ||
Line 163: | Line 187: | ||
</ | </ | ||
+ | </ | ||
+ | <file xml | LateralInhibition_2cell.xml> | ||
+ | |||
+ | <?xml version=' | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | </ | ||
+ | < | ||
+ | <Lattice class=" | ||
+ | < | ||
+ | < | ||
+ | </ | ||
+ | <Size symbol=" | ||
+ | </ | ||
+ | < | ||
+ | </ | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | </ | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | <System solver=" | ||
+ | <DiffEqn symbol-ref=" | ||
+ | < | ||
+ | - k * A</ | ||
+ | </ | ||
+ | <DiffEqn symbol-ref=" | ||
+ | < | ||
+ | - k * A_neighbour</ | ||
+ | </ | ||
+ | </ | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | </ | ||
+ | < | ||
+ | <Logger time-step=" | ||
+ | < | ||
+ | <Symbol symbol-ref=" | ||
+ | </ | ||
+ | < | ||
+ | < | ||
+ | </ | ||
+ | < | ||
+ | <Plot time-step=" | ||
+ | <Style style=" | ||
+ | < | ||
+ | < | ||
+ | <Symbol symbol-ref=" | ||
+ | </ | ||
+ | < | ||
+ | <Symbol symbol-ref=" | ||
+ | <Symbol symbol-ref=" | ||
+ | </ | ||
+ | </ | ||
+ | </ | ||
+ | </ | ||
+ | </ | ||
+ | </ | ||
+ | |||
+ | |||
+ | </ | ||
+ | |||
+ | <file xml | LateralInhibition_space.xml> | ||
+ | |||
+ | <?xml version=' | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | </ | ||
+ | < | ||
+ | <Lattice class=" | ||
+ | < | ||
+ | < | ||
+ | </ | ||
+ | <Size symbol=" | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | </ | ||
+ | </ | ||
+ | < | ||
+ | </ | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | </ | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | <Input scaling=" | ||
+ | <Output symbol-ref=" | ||
+ | </ | ||
+ | <System solver=" | ||
+ | <DiffEqn symbol-ref=" | ||
+ | < | ||
+ | - X</ | ||
+ | </ | ||
+ | </ | ||
+ | </ | ||
+ | </ | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | </ | ||
+ | --> | ||
+ | < | ||
+ | </ | ||
+ | </ | ||
+ | </ | ||
+ | < | ||
+ | < | ||
+ | < | ||
+ | <Cells value=" | ||
+ | </ | ||
+ | < | ||
+ | </ | ||
+ | </ | ||
+ | < | ||
+ | < | ||
+ | </ | ||
+ | </ | ||
</ | </ | ||
documentation/course/module1.1510581160.txt.gz · Last modified: 14:52 13.11.2017 by Fabian Rost