Table of Contents
Description
Multicellular systems biology is an emerging field aiming at a mechanistic understanding of developmental, physiological and pathological processes by studying the multiscale interactions at the subcellular, cellular and tissue levels. Increasingly, computational simulation is needed to explore and predict a system’s behavior and to integrate quantitative data.
Recently, a number of dedicated modeling and simulation platforms have become available that facilitate the construction and simulation of multiscale models of multicellular systems. It is therefore time for a comprehensive overview and comparison of challenges and approaches of the different modeling platforms in multicellular systems biology.
This mini-symposium, colocated at the ECMTB in Gothenburg, presents the state-of-the-art in computational methods for multicellular systems biology. It brings together developers and users of this software to identify common approaches and future challenges concerning multiscale integration, model specification, model exchange, scalability, workflow management as well as compliance to standards and guidelines. The session thus aims to provide an overview of the available modeling and simulation platforms and accelerate innovation in the field of computational multicellular systems biology.
Organizers
- Walter de Back, Technische Universität Dresden
- Thomas Sütterlin, BioQuant, Heidelberg University
- Andreas Deutsch, Technische Universität Dresden
- Niels Grabe, BioQuant, Heidelberg University
Abstracts
We have compiled a book of abstracts for this minisymposium.
Speakers
| Platform | Speaker / Affiliation | Title | Abstracts |
|---|---|---|---|
| | Alex Fletcher Mathematical Institute University of Oxford, UK | Chaste: An open source C++ library for computational physiology and biology | Abstract |
 | Maciej Swat Biocomplexity Institute Department of Physics Indiana University, USA | Modeling tissues using CompuCell3D | Abstract |
 | Thomas Sütterlin Department of medical oncology University Hospital Heidelberg, Germany & Tissue Imaging and Analysis Center, BioQuant, Heidelberg University, Germany | EPISIM Platform: Graphical multi-scale modeling and simulation of multicellular systems | Abstract |
 | Roeland Merks Centrum Wiskunde & Informatica Amsterdam, NL and Mathematical Institute University Leiden, NL | Modeling animal tissues in VirtualLeaf: Towards an off-lattice cellular 'Potts' model | Abstract |
 | Tim Johann Interdisciplinary Center for Bioinformatics (IZBI) Universität Leipzig, Germany | CellSys: Modular software for physics-based tissue modelling in 3D | Abstract |
 | Ryan Tasseff Institute for Systems Biology Seattle, USA | Biocellion: Accelerating multicellular biological simulation | Abstract |
| | Walter de Back Center for Information Services and High Performance Computing Technische Universität Dresden, Germany | Morpheus: User-friendly modeling of multicellular systems | Abstract |
Time Schedule
- Date: Thursday June 19 2014
- Time: 09:00 - 13:00
- Presentations: 20 minutes + 5 min discussion
| Time | Speaker |
|---|---|
| 09:00 - 09:10 | Introduction |
| 09:10 - 09:35 | Alex Fletcher |
| 09:35 - 10:00 | Maciej Swat |
| 10:00 - 10:30 | Coffee break |
| 10:30 - 10:55 | Thomas Sütterlin |
| 10:55 - 11:20 | Roeland Merks |
| 11:20 - 11:45 | Tim Johann |
| 11:45 - 12:10 | Ryan Tasseff |
| 12:10 - 12:35 | Walter de Back |
| 12:35 - 13:00 | Round table discussion |
