¹ Center for Information Services and High Performance Computing, Technical University Dresden, 01062, Dresden, Germany.
² Institute of Physics of Liquids and Biological Systems (IFLYSIB), CONICET, University of La Plata, 59-789, B1900BTE, La Plata, Argentina.
Amputation of body parts in mammals induces a wound healing process which leads to scar formation. In contrast, some organisms are able to regenerate the lost body part after amputation. Among them, the freshwater polyp Hydra and planarian flatworms regenerate the entire body plan from almost any small body fragment. The zebrafish regenerates fins and parts of the eye, heart, and brain. The axolotl (Amblystoma mexicanum) is able to regenerate the entire limb after upper-limb amputation.
Despite the spectacular experimental knowledge gained during almost 270 years since the original discovery of Hydra regeneration by Abraham Trembley in 1744, many questions still remain unanswered. Are the regenerative processes conserved among the animals capable of regeneration? Are the regenerative processes re-activating dormant developmental programs? Or they constitute an adaptive trait and a result of natural selection?
Although the underlying mechanisms are still elusive it is well known that many complex signaling pathways are activated. The complexity of these pathways attracted many and interesting mathematical modelling efforts in other biological contexts like development or cancer.
Comparatively fewer mathematical models have been developed for regenerative processes of animals so far. In this mini-Symposium we bring together well-recognized speakers with seminal contributions in the area of mathematical modelling of regeneration as well as young modelers who presented promising ideas or results in this field.
|11:40 – 11:50||Osvaldo Chara , Lutz Brusch and Andreas Deutsch||Brief welcome to the Mini-Symposium and introduction.|
|11:50 – 12:40|| Hans Meinhardt |
Max-Planck-Institut für Entwicklungsbiologie, Spemannstr. 35, D-72076 Tübingen, Germany.
|Models for regeneration: reconciling pattern formation and growth.||Abstract|
|12:40 – 14:00||Lunch break|
|14:00 – 14:30|| Qing Nie |
Department of Mathematics, Department of Biomedical Engineering, Center for Mathematical and Computational Biology, and Center for Complex Biological Systems, University of California, Irvine, U.S.
|Stem Cells and Regeneration: Feedback, Niche, and Epigenetic Regulation.||Abstract|
|14:30 – 15:00|| Fred Vermolen |
Delft Institute of Applied Mathematics, Delft University of Technology. Mekelweg 4, 2628 CD Delft. The Netherlands, Office EWI HB03.310.
|A mathematical model for cell differentiation, as an evolutionary and regulated process.||Abstract|
|15:00 – 15:30|| Osvaldo Chara |
Center for Information Services and High Performance Computing, Technical University Dresden, 01062, Dresden, Germany, and Institute of Physics of Liquids and Biological Systems (IFLYSIB), CONICET, University of La Plata, 59-789, B1900BTE, La Plata, Argentina.
|A quantitative data-driven model of cell proliferation and cell migration in the axolotl spinal cord regeneration.||Abstract|
|15:30 – 16:00|| Aurélie Carlier |
Biomechanics Section, Faculty of Engineering - KU Leuven, Celestijnenlaan 300 - bus 2419, B-3001 Heverlee, Belgium
|Unraveling the occurrence of fracture non-unions with a multiscale bioregulatory model.||Abstract|